06 · WHAT IS ESTABLISHED — AND WHAT IS NOT
Useful evidence.
Clear boundaries.
The strongest evidence supports the construct and its association with mobility limitation in Japanese populations. Translation into an individual prognosis or a universal screening programme requires caution.
2007Concept introduced
The JOA introduced locomotive syndrome as a framework linking locomotor disorders, mobility and future care needs. [02]
2020Stage 3 added
Clinical decision limits were revised to distinguish severe decline affecting social participation. [01]
6 yearsLongitudinal follow-up
In the Japanese ROAD cohort, stage 3 was associated with subsequent disability and mortality. This is an association, not an individual forecast. [04]
JapanEvidence geography
Most prevalence, threshold and outcome data originate in Japan; estimates should not be transplanted directly to other populations. [08]
COHORTA useful Japanese reference — not a European prevalence estimate
Using the updated criteria in the ROAD cohort, mutually exclusive prevalence estimates were 41.3% for stage 1, 14.9% for stage 2 and 11.6% for stage 3. The cohort’s age structure and Japanese context matter. [04]
AGEIs it only relevant after 65?
Cross-sectional studies have identified abnormal test results in working-age adults, but this does not establish benefit from universal screening from age 30. Outside Japan, age thresholds, pathways and cost-effectiveness remain to be established. [06]
EstablishedJOA definition; three-component framework; 2020 thresholds; associations with mobility limitation.
Context-dependentPrevalence, prognosis and optimal reassessment interval outside Japanese cohorts.
ResearchPersonalised trajectories, composite scores, movement age and prediction of individual outcomes.